Should you be consuming NMN supplements?
If you are someone above 30 who wishes to live a long and healthy life, we would say yes. You should!
Let us explain the 'why' in detail.
What is an NMN Supplement?
NMN or Nicotinamide Mononucleotide is a compound that acts as a precursor to nicotinamide adenine dinucleotide (NAD+), a coenzyme found in all living cells. NAD+ plays a crucial role in various biological functions, including energy metabolism, DNA repair, and gene expression regulation. (1)
All activities that ensure we continue to live!
With age, our NAD+ levels decline. And so does our ability to live a life full of good health and vitality. This is exactly where a good NMN supplement can help! Studies spanning over the last two decades suggest that NMN supplementation can increase NAD+ levels in human cells, which could potentially have anti-aging effects and improve various aspects of our well-being. (1)
How Do NMN supplements work?
Nicotinamide mononucleotide (NMN) increases nicotinamide adenine dinucleotide (NAD+) levels by serving as a precursor molecule that undergoes enzymatic conversion to NAD+ within our cells. Upon uptake, NMN is metabolized by an enzyme through a series of reactions, ultimately resulting in the synthesis of NAD+. (2)
NAD+ functions as a critical cofactor for enzymes, including sirtuins, involved in various cellular processes such as DNA repair, gene expression regulation, and metabolism. Sirtuins, particularly SIRT1, are dependent on NAD+ for their enzymatic activity, and by increasing NAD+ levels, NMN supplementation enhances sirtuin activity, potentially promoting cellular health and mitigating age-related decline in NAD+ levels. (2)
What are the Benefits of NMN supplementation?
Increased NAD+ Levels
As discussed above, NMN is a precursor to NAD+ (Nicotinamide Adenine Dinucleotide), a coenzyme involved in various cellular processes, including energy metabolism, DNA repair, and gene expression regulation. By increasing NAD+ levels, NMN supplementation may support overall cellular health and function.
Improved Energy Metabolism
NAD+ plays a crucial role in cellular energy production, particularly in the mitochondria, where it participates in the electron transport chain. By enhancing NAD+ levels, NMN supplementation supports mitochondrial function and improves energy metabolism, potentially leading to increased energy levels and endurance.
Enhanced DNA Repair
NAD+ promotes the activity of enzymes involved in DNA repair, such as poly (ADP-ribose) polymerases (PARPs). By supporting NAD+ levels, NMN supplementation enhances DNA repair mechanisms, protecting cells from DNA damage and reducing the risk of age-related diseases.
Activation of Sirtuins
Sirtuins are a class of NAD+-dependent enzymes involved in various cellular processes. NMN supplementation is known to improve sirtuin activity by increasing NAD+ availability, promoting your cellular health.
Potential Anti-Aging Effects
Given its role in cellular metabolism, DNA repair, and gene expression regulation, NMN supplementation has been proposed to have anti-aging effects. Research suggests that NMN supplementation can improve various markers of aging, including muscle function, cognitive function, and lifespan.
Cardiovascular Health
Some studies link regular NMN supplementation with better cardiovascular health, including improved endothelial function, reduced inflammation, and protection against oxidative stress. Such effects can potentially lower the risk of cardiovascular diseases and stroke.
Which is the Best NMN Supplement available in India?
If you're convinced to start with NMN, this guide will help you choose the best supplement in India. Here's what you should be looking out for!
Purity and Quality
Look for NMN supplements that are manufactured by reputable companies and adhere to strict quality control standards. Check for third-party certifications, such as FDA, which ensure that the product meets purity and quality standards.
Ingredients
Check the ingredient list to ensure that the NMN supplement does not contain any unnecessary fillers, additives, or preservatives. The fewer additional ingredients, the better!
Dosage
Research suggests that effective doses of NMN typically range from 100 mg to 1000 mg per day. Choose a supplement that provides a dosage suitable for your needs and preferences.
Formulation
NMN supplements are available in various forms, including capsules, powders, and sublingual tablets. Choose a formulation that is convenient for you to take and fits your lifestyle.
Bioavailability
NMN has low oral bioavailability, meaning that not all of it is absorbed by the body when taken orally. Look for NMN supplements that utilize technologies or ingredients to enhance bioavailability, such as liposomal delivery systems or co-administration with compounds like resveratrol.
Research and Evidence
Pay attention to scientific research and evidence supporting the efficacy and safety of the NMN supplement you're considering. Look for clinical studies, peer-reviewed papers, and expert opinions that validate the claims made by the manufacturer!
Consultation with Healthcare Provider
Before starting any new supplement regimen (especially if you have underlying health conditions, are already on medications, are pregnant, or lactating), it's advisable to consult with your healthcare provider to ensure that NMN supplementation is appropriate for you or not.
Our premium beta-NMN powder has been meticulously crafted for unparalleled purity and potency. Unlike conventional NMN supplements that often contain the less effective alpha form, our product exclusively harnesses the superior beta form for maximum bioactivity.
Our fast-dissolve powder boasts over 99.5% purity, ensuring you receive nothing but the highest quality NMN. Designed for sublingual delivery, it bypasses the digestive system and liver metabolism, allowing for direct absorption into the bloodstream, a process that enhances its bioavailability and efficacy.
Our beta-NMN powder is derived enzymatically, ensuring its purity and potency without resorting to chemical synthesis. We subject our product to rigorous third-party testing for heavy metals, pesticides, and contaminants, providing you with assurance regarding its safety and efficacy.
What is the right dosage and time to consume NMN?
It's essential to note that NMN supplementation is still an area of ongoing research, and there isn't a universally agreed-upon "right" dosage or timing for its consumption.
That said, dosages commonly used in research studies range from around 100 mg to 1000 mg per day, with some studies even using higher doses. However, individual responses to NMN supplementation may vary based on factors such as age, weight, overall health, and metabolic rate. (3)
As for the timing of consumption, there's currently no consensus. Some people prefer to take NMN in the morning with breakfast, while others prefer to take it later in the day. Since NMN is water-soluble, it can be taken with or without food. However, it's generally advisable to follow the instructions provided by the manufacturer or consult with a healthcare professional for personalized advice based on your specific health needs and circumstances. (3)
If you're consuming xLongevity's NMN power, we recommend you take one scoop daily, with or without food, or follow the guidance of your healthcare professional. Make sure that you hold the NMN powder under your tongue for 45-60 seconds before swallowing.
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References
1. The Science Behind NMN–A Stable, Reliable NAD+Activator and Anti-Aging Molecule - PMC (nih.gov)